Principles of Molecular Medicine

Principles of Molecular Medicine is the first major textbook to integrate the basic principles of internal medicine with the rapidly growing body of revolutionary findings from cell and molecular biology, including the human genome project. In its pages, J. Larry Jameson and his authoritative contributors, many of them world-renowned clinicians and researchers, expand the envelope of clinical understanding to encompass a wide array of specialties-including neurology, cardiology, hematology, nephrology, genetics, endocrinology, oncology, dermatology, and psychiatry-revealing the underlying molecular mechanisms of disease, as well as novel routes to the unprecedented treatments now emerging from these new molecular approaches. Practicing physicians will find informative updates in both their own specialties and in disciplines they may not have been able to follow closely. Within the framework of clinical internal medicine, they will gain critical knowledge of the many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more. Principles of Molecular Medicine offers a brilliant and original synthesis of today's rapidly advancing insights-fostered by genetics and molecular biology-into the nature and treatment of disease, codifying the major paradigm shift now underway in the teaching and practice of medicine. Certain to become a vital complement to traditional medical textbooks, Principlesof Molecular Medicine provides practicing physicians, residents, medical students, and researchers alike with an authoritative and practical account of today's internal medicine, as well as insights into the nature and direction of future developments.